Table 1:
The binding energy of the studied xacins into Human Topo I, II and III.
| Topo I |
-Energy (kcal/mol) |
Topo II |
-Energy (kcal/mol) |
Topo III |
-Energy (kcal/mol) |
| Grepafloxacin |
36.0815 |
Alatrofloxacin |
56.7101 |
Alatrofloxacin |
56.9448 |
| Moxifloxacin |
35.8569 |
Grepafloxacin |
55.1212 |
Temafloxacin |
50.0223 |
| Temafloxacin |
35.7147 |
Gatifloxacin |
53.571 |
Enoxacin |
45.0582 |
| Tosufloxacin |
35.4954 |
Gemifloxacin |
53.4783 |
Lomefloxacin |
45.0336 |
| Pipemidic acid |
35.4817 |
Nadifloxacin |
53.2681 |
Moxifloxacin |
44.3815 |
| Gemifloxacin |
35.4202 |
Trovafloxacin |
53.2223 |
Tosufloxacin |
43.8647 |
| Enoxacin |
35.0297 |
Sparfloxacin |
53.1397 |
Ciprofloxacin |
43.0485 |
| Trovafloxacin |
34.7043 |
Moxifloxacin |
53.1133 |
Gemifloxacin |
42.6540 |
| Sparfloxacin |
32.8721 |
Ofloxacin |
51.1086 |
Gatifloxacin |
42.5980 |
| Levofloxacin |
31.2864 |
Temafloxacin |
50.6039 |
Pipemidic acid |
42.1612 |
| Ofloxacin.cdx |
30.6022 |
Tosufloxacin |
50.5345 |
Nadifloxacin |
41.5925 |
| Pefloxacin.cdx |
30.4232 |
Lomefloxacin |
50.4750 |
Sparfloxacin |
41.5637 |
| Lomefloxacin |
30.3799 |
Levofloxacin |
49.7114 |
Fleroxacin |
40.8749 |
| Ciprofloxacin |
30.3107 |
Norfloxacin |
48.8138 |
Trovafloxacin |
40.6068 |
| Nalidixic acid |
30.2423 |
Rufloxacin |
48.5927 |
Rufloxacin |
39.9158 |
| Norfloxacin |
29.9207 |
Fleroxacin |
47.5199 |
Ofloxacin |
39.2124 |
| Fleroxacin |
29.6700 |
Ciprofloxacin |
47.3246 |
Levofloxacin |
39.1278 |
| Gatifloxacin |
29.5761 |
Enoxacin |
45.7953 |
Pefloxacin |
38.9657 |
| Nadifloxacin |
29.2942 |
Pefloxacin |
45.2658 |
Norfloxacin |
37.9596 |
| Rufloxacin |
27.0945 |
Pipemidic acid |
42.8552 |
Grepafloxacin |
37.3532 |
| Alatrofloxacin |
Failed |
Nalidixic acid |
35.8082 |
Nalidixic acid |
35.4947 |