Table 1:

The binding energy of the studied xacins into Human Topo I, II and III.
Topo I -Energy (kcal/mol) Topo II -Energy (kcal/mol) Topo III -Energy (kcal/mol)
Grepafloxacin 36.0815 Alatrofloxacin 56.7101 Alatrofloxacin 56.9448
Moxifloxacin 35.8569 Grepafloxacin 55.1212 Temafloxacin 50.0223
Temafloxacin 35.7147 Gatifloxacin 53.571 Enoxacin 45.0582
Tosufloxacin 35.4954 Gemifloxacin 53.4783 Lomefloxacin 45.0336
Pipemidic acid 35.4817 Nadifloxacin 53.2681 Moxifloxacin 44.3815
Gemifloxacin 35.4202 Trovafloxacin 53.2223 Tosufloxacin 43.8647
Enoxacin 35.0297 Sparfloxacin 53.1397 Ciprofloxacin 43.0485
Trovafloxacin 34.7043 Moxifloxacin 53.1133 Gemifloxacin 42.6540
Sparfloxacin 32.8721 Ofloxacin 51.1086 Gatifloxacin 42.5980
Levofloxacin 31.2864 Temafloxacin 50.6039 Pipemidic acid 42.1612
Ofloxacin.cdx 30.6022 Tosufloxacin 50.5345 Nadifloxacin 41.5925
Pefloxacin.cdx 30.4232 Lomefloxacin 50.4750 Sparfloxacin 41.5637
Lomefloxacin 30.3799 Levofloxacin 49.7114 Fleroxacin 40.8749
Ciprofloxacin 30.3107 Norfloxacin 48.8138 Trovafloxacin 40.6068
Nalidixic acid 30.2423 Rufloxacin 48.5927 Rufloxacin 39.9158
Norfloxacin 29.9207 Fleroxacin 47.5199 Ofloxacin 39.2124
Fleroxacin 29.6700 Ciprofloxacin 47.3246 Levofloxacin 39.1278
Gatifloxacin 29.5761 Enoxacin 45.7953 Pefloxacin 38.9657
Nadifloxacin 29.2942 Pefloxacin 45.2658 Norfloxacin 37.9596
Rufloxacin 27.0945 Pipemidic acid 42.8552 Grepafloxacin 37.3532
Alatrofloxacin Failed Nalidixic acid 35.8082 Nalidixic acid 35.4947