Table 3:

Listing of known hydroxylation sites on warfarin or phenprocoumon.
Hydroxylation sites References Comments
(R)- and (S)-PPC at C6 [41,83,84] Negligible amount for both enantiomeric forms
PPC at C7 [41,83,84] Main metabolite for S-PPC and negligible amount of R-PPC
PPC at C8 [41,84] Negligible amount in the blood plasma
PPC at C4' [41,83,84] Main metabolite for S-PPC and negligible amount of R-PPC
PPC at C2' [84] Figure 1 and Figure 2
(R)-WFN at C4´ [85] By CYP2C9 in negligible amount
(R)-WFN at C6 [86] By CYP1A1 and CYP1A2
(R)-WFN at C8 [86,87] By CYP1A1, CYP1A2 and the main enzyme CYP2C19
(R)-WFN at C10 [87] By CYP3A4
(S)-WFN at C6 [41,88] By CYP2C9; negligible (S)- C6 metabolite
(S)-WFN at C7 [41,85] By CYP2C9, main metabolite